Patient P-03065
Immune response 93 at the day-84 endpoint (observed).
Responding: response probability 82%, immune response 82 today; biology is not blocking the drug.
No side effect starting: immune-related gi adverse events 19, immune-related toxicity 0, no drift from the model.
5 of 5 scheduled doses in the last 60 days are biologically confirmed (100%). Dose signature: resting HR +5 bpm, HRV −5 ms.
Trajectory is stable relative to similar patients; keep the current content.
- 🍽Keep meals regular; three to four moderate portions spaced through the day
- 🍽Include a cooked vegetable portion with each main meal
- ✓Log the daily check-in; one line is enough
- ✓A 15-minute walk after lunch
- 💊Take the scheduled dose as agreed with your care team
- 💊No additional supplements this week
Adherence is not the problem.
sleep quality falling under 35 while GI rises
P-03065 is on day 129 of ONX-7 (SR, baseline S08): response favorable, tolerance improving, GI deteriorating. Over 14 days response moved +3 and GI +6; discontinuation risk is 14%. The state is in the restoration basin, heading towards restoration.
Butyrate capacity 72/100, diversity 4.4, normal metabolizer. Pushing it down: Escherichia coli 6.179% (LPS load) (-23.8), Alcohol (-14.3), Bacteroides fragilis elevated (-13). Pulling it up: Protein (supports) (+13.3), Butyrate producers intact (+13.1). From the daily log: alcohol +4.3 GI next day, protein -3.5 GI next day.
No action has been tried yet.
No action is indicated now; the trajectory is stable relative to similar patients.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 ONX-7 started — Baseline state S08
What changed?
Trajectory is tracking the baseline prediction.
- Toxicity-9
- GI instability+6
- Inflammatory activity-5
- Nutritional resilience+3
What helped?
No interventions yet.
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards restoration · 94 from the failing basin, 9 from restoration.
- Protein (supports)perturbation · steering +13.3
- Butyrate producers intacthidden · steering +13.1
- Proteinsupporter · GI -3.5 next day
- Escherichia coli 6.179% (LPS load)hidden · steering -23.8
- Alcoholperturbation · steering -14.3
- Bacteroides fragilis elevatedhidden · steering -13
- H2S production above bandhidden · steering -11.6
- Alcoholdetractor · GI +4.3 next day
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Alcohol+4.3detractor · 95%
- Protein-3.5supporter · 95%
- Lactose+1.8no signal · 42%
- Histamine load-1.4no signal · 34%
- Caffeine+0.6no signal · 15%
- Dietary fat load-0.1no signal · 15%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 3 opportunists above range: Escherichia coli, Enterococcus faecium, Streptococcus gallolyticus
- 1 keystone species absent
- 2 resistance genes
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Inflammatory signalling ↓35
- MicrobiomeBacteroides fragilis expansion
- WearableHRV 35 ms, trending down
- Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
- Autonomic recovery ↑20
- Wearable2,610 steps/day
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Normal metabolizerExpected exposure
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
- HRV
- 36 ms
- Sleep
- 6.9 h
- Steps
- 4,098
- Resting HR
- 70 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Keep fibre steady; no new sources this week
- Avoid known triggers for now: fried or oily food, dairy, alcohol
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.