Patient P-03167
Immune response 82 at the day-84 endpoint (observed).
Responding: response probability 77%, immune response 74 today; biology is not blocking the drug.
No side effect starting: immune-related gi adverse events 10, immune-related toxicity 14, no drift from the model.
3 of 4 scheduled doses in the last 60 days are biologically confirmed (75%); 1 were logged but show no dose signature. Dose signature: resting HR +3 bpm, HRV −8 ms.
Trajectory is stable relative to similar patients; keep the current content.
- 🍽Keep meals regular; three to four moderate portions spaced through the day
- 🍽Include a cooked vegetable portion with each main meal
- ✓Log the daily check-in; one line is enough
- ✓A 15-minute walk after lunch
- 💊Take the scheduled dose as agreed with your care team
- 💊No additional supplements this week
Adherence is not the problem.
sleep quality falling under 35 while GI rises
P-03167 is on day 140 of ONX-7 (SR, baseline S10): response declining, tolerance favorable, GI favorable. Over 14 days response moved -6 and GI -2; discontinuation risk is 6%. The state is in the restoration basin, heading towards failing.
Biology sets the gain: Poor metabolizer; butyrate capacity 75/100, diversity 3.0. Pushing it down: Poor metabolizer (-23.9), Enterococcus faecium 4.713% (LPS load) (-23.3), Caffeine (-17.7). Pulling it up: Protein (supports) (+25.7), Butyrate producers intact (+14). From the daily log: protein -6.1 GI next day, caffeine +4.7 GI next day, alcohol +4.3 GI next day, lactose +4.2 GI next day.
No action has been tried yet.
No action is indicated now; the trajectory is stable relative to similar patients.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 ONX-7 started — Baseline state S10
What changed?
Trajectory is tracking the baseline prediction.
- Treatment adherence+7
- Inflammatory activity-4
- Nutritional resilience+4
- GI instability-2
- Toxicity+2
What helped?
No interventions yet.
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards failing · 90 from the failing basin, 9 from restoration.
- No untried action with strong evidence. Compose one from primitives.
- More proteinGI -6.1 next day on high-intake days · n 24
- Keep caffeine lowGI +4.7 next day on high-intake days · n 15
- Keep alcohol lowGI +4.3 next day on high-intake days · n 21
- Keep lactose lowGI +4.2 next day on high-intake days · n 18
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-6.1supporter · 95%
- Caffeine+4.7detractor · 95%
- Alcohol+4.3detractor · 95%
- Lactose+4.2detractor · 95%
- Histamine load-1.3no signal · 32%
- Dietary fat load+0.8no signal · 17%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 3 opportunists above range: Klebsiella pneumoniae, Enterococcus faecium, Streptococcus gallolyticus
- 1 keystone species absent
- 5 resistance genes
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Drug metabolism and exposure ↑40
- DNACYP2D6 poor metabolizer → higher exposure
- Autonomic recovery ↓40
- Wearable3,676 steps/day
- WearableShort sleep window
- Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer
- Inflammatory signalling ↓20
- MicrobiomeBacteroides fragilis expansion
- CYP2D6 Poor metabolizerHigher exposure at standard dose
- MTHFR C677TReduced folate turnover
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
- HRV
- 54 ms
- Sleep
- 6.4 h
- Steps
- 3,420
- Resting HR
- 65 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Keep fibre steady; no new sources this week
- Avoid known triggers for now: fried or oily food, dairy, alcohol
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.