Patient P-03418
Immune response 59 at the day-84 endpoint (observed).
Responding: response probability 39%, immune response 40 today; biology is not blocking the drug.
Drift detected on day 105 (sleep −0.7 h); nothing reported yet — the window to act is open.
4 of 4 scheduled doses in the last 60 days are biologically confirmed (100%). Dose signature: resting HR +7 bpm, HRV −9 ms.
Trajectory is stable relative to similar patients; keep the current content.
- 🍽Keep meals regular; three to four moderate portions spaced through the day
- 🍽Include a cooked vegetable portion with each main meal
- ✓Log the daily check-in; one line is enough
- ✓A 15-minute walk after lunch
- 💊Take the scheduled dose as agreed with your care team
- 💊No additional supplements this week
Adherence is not the problem.
sleep quality falling under 35 while GI rises
P-03418 is on day 125 of ONX-7 (EC-01, baseline S18): response unstable, tolerance favorable, GI improving. Over 14 days response moved +3 and GI -8; discontinuation risk is 11%. The state is between basins, heading towards restoration, after diverging from the model on day 105.
Biology sets the gain: Low butyrate capacity, Low microbial diversity; butyrate capacity 37/100, diversity 2.2. Pushing it down: Low butyrate capacity (-30), Enterococcus faecium 9.962% (LPS load) (-28), 4 keystone species absent (-22.5). Pulling it up: Behavioural Recommendation BR-03 (+15.1), Protein (supports) (+14.2). From the daily log: fat +3.7 GI next day, lactose +3.6 GI next day, protein -3.6 GI next day.
Past actions: BR-03 on day 91 → improved (12%).
No action is indicated now; the trajectory is stable relative to similar patients.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 ONX-7 started — Baseline state S18
- Day 90 BR-03 recommended — Behavioural Recommendation BR-03
- Day 91 Patient accepted — Started BR-03 in the companion
- Day 98 GI symptom burden −12% vs expected — Behavioural Recommendation BR-03
- Day 104 Tolerance state changed — Unstable → Improving
- Day 105 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 105.
- GI instability-8
- Inflammatory activity-6
- Nutritional resilience+5
- Treatment adherence-4
- Toxicity+2
What helped?
- Behavioural Recommendation BR-03Day 90Result: symptom burden −12%
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards restoration · 71 from the failing basin, 38 from restoration.
- Behavioural Recommendation BR-03intervention · steering +15.1
- Protein (supports)perturbation · steering +14.2
- Daily walks resumedperturbation · steering +3.3
- Proteinsupporter · GI -3.6 next day
- Low butyrate capacityhidden · steering -30
- Enterococcus faecium 9.962% (LPS load)hidden · steering -28
- 4 keystone species absenthidden · steering -22.5
- Tissue recycling 46/100hidden · steering -14.4
- Dietary fat loaddetractor · GI +3.7 next day
- Lactosedetractor · GI +3.6 next day
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+3.7detractor · 95%
- Lactose+3.6detractor · 95%
- Protein-3.6supporter · 95%
- Alcohol+1.4no signal · 41%
- Caffeine-0.4no signal · 15%
- Histamine load0no signal · 15%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 2 opportunists above range: Enterococcus faecium, Clostridioides difficile
- 4 keystone species absent
- Shannon 2.63 (expected ≥ 3)
- 8 resistance genes
- Tissue recycling index 46
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 37/100
- MicrobiomeF. prausnitzii depleted
- Mucosal barrier integrity ↓40
- MicrobiomeAkkermansia low → thinner mucus layer
- WearableSleep 6.0 h, below personal baseline
- Autonomic recovery ↑20
- WearableShort sleep window
- Inflammatory signalling ↓15
- WearableHRV 35 ms, trending down
- CYP2D6 Normal metabolizerExpected exposure
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
- HRV
- 32 ms
- Sleep
- 6.0 h
- Steps
- 3,384
- Resting HR
- 69 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.