500 patients67,039 observations150 daysLIVE

110 trajectories in Moderate responders

Trajectories

Synthetic demo data

All Strong responders · 120 Moderate responders · 110 Non-responders · 75 Early toxicity · 40 Late toxicity · 40 Delayed loss of response · 45 Resilient responder · 42 High response / high intolerance · 28

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-03052D145 · risk 59%

StableDeterioratingresp 44

P-03429D143 · risk 40%

ImprovingDeterioratingresp 68

P-03074D142 · risk 34%

StableDeterioratingresp 60

P-03101D147 · risk 29%

ImprovingDeterioratingresp 65

P-03434D149 · risk 26%

DecliningDeterioratingresp 52

P-03309D147 · risk 22%

FavorableFavorableresp 61

P-03403D144 · risk 20%

ImprovingFavorableresp 65

P-03262D139 · risk 18%

FavorableFavorableresp 62

P-03196D147 · risk 17%

StableFavorableresp 60

P-03381D140 · risk 16%

StableFavorableresp 55

P-03266D148 · risk 15%

FavorableFavorableresp 73

P-03217D141 · risk 12%

StableImprovingresp 52