500 patients67,039 observations150 daysLIVE

75 trajectories in Non-responders

Trajectories

Synthetic demo data

All Strong responders · 120 Moderate responders · 110 Non-responders · 75 Early toxicity · 40 Late toxicity · 40 Delayed loss of response · 45 Resilient responder · 42 High response / high intolerance · 28

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-03437D139 · risk 59%

UnstableDeterioratingresp 31

P-03355D138 · risk 36%

UnstableDeterioratingresp 31

P-03162D105 · risk 27%

UnstableDeterioratingresp 28

P-03131D142 · risk 22%

UnstableFavorableresp 30

P-03104D139 · risk 20%

UnstableImprovingresp 27

P-03053D132 · risk 18%

UnstableFavorableresp 39

P-03130D96 · risk 17%

UnstableImprovingresp 19

P-03229D135 · risk 16%

UnstableImprovingresp 35

P-03316D124 · risk 15%

UnstableImprovingresp 37

P-03400D147 · risk 13%

UnstableFavorableresp 31

P-03330D142 · risk 12%

UnstableImprovingresp 24

P-03454D145 · risk 11%

UnstableFavorableresp 34