500 patients67,039 observations150 daysLIVE

40 trajectories in Early toxicity

Trajectories

Synthetic demo data

All Strong responders · 120 Moderate responders · 110 Non-responders · 75 Early toxicity · 40 Late toxicity · 40 Delayed loss of response · 45 Resilient responder · 42 High response / high intolerance · 28

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-03044D90 · risk 44%

DecliningDeterioratingresp 45

P-03214D142 · risk 35%

ImprovingDeterioratingresp 68

P-03484D145 · risk 32%

StableDeterioratingresp 49

P-03375D138 · risk 26%

ImprovingDeterioratingresp 52

P-03203D93 · risk 24%

StableDeterioratingresp 56

P-03193D115 · risk 21%

StableDeterioratingresp 53

P-03040D96 · risk 18%

ImprovingFavorableresp 51

P-03198D141 · risk 15%

StableFavorableresp 52

P-03268D141 · risk 14%

ImprovingFavorableresp 56

P-03442D140 · risk 13%

DecliningImprovingresp 51

P-03062D142 · risk 10%

DecliningImprovingresp 44

P-03489D129 · risk 10%

DecliningImprovingresp 54