500 patients67,039 observations150 daysLIVE

40 trajectories in Late toxicity

Trajectories

Synthetic demo data

All Strong responders · 120 Moderate responders · 110 Non-responders · 75 Early toxicity · 40 Late toxicity · 40 Delayed loss of response · 45 Resilient responder · 42 High response / high intolerance · 28

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-03285D119 · risk 94%

StableUnstableresp 54

P-03099D148 · risk 74%

StableUnstableresp 55

P-03292D108 · risk 66%

FavorableDeterioratingresp 62

P-03080D145 · risk 62%

FavorableUnstableresp 62

P-03218D109 · risk 61%

ImprovingDeterioratingresp 56

P-03352D150 · risk 58%

ImprovingUnstableresp 59

P-03444D148 · risk 56%

ImprovingImprovingresp 62

P-03451D122 · risk 54%

FavorableUnstableresp 62

P-03160D106 · risk 52%

ImprovingDeterioratingresp 63

P-03357D148 · risk 49%

DecliningImprovingresp 50

P-03166D143 · risk 47%

ImprovingImprovingresp 62

P-03201D139 · risk 46%

ImprovingStableresp 68