500 patients67,039 observations150 daysLIVE

42 trajectories in Resilient responder

Trajectories

Synthetic demo data

All Strong responders · 120 Moderate responders · 110 Non-responders · 75 Early toxicity · 40 Late toxicity · 40 Delayed loss of response · 45 Resilient responder · 42 High response / high intolerance · 28

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-03283D123 · risk 45%

ImprovingDeterioratingresp 96

P-03270D142 · risk 36%

FavorableDeterioratingresp 71

P-03259D147 · risk 33%

ImprovingDeterioratingresp 80

P-03028D150 · risk 29%

FavorableDeterioratingresp 73

P-03322D149 · risk 23%

ImprovingDeterioratingresp 80

P-03458D104 · risk 22%

FavorableDeterioratingresp 81

P-03125D141 · risk 17%

FavorableDeterioratingresp 76

P-03066D140 · risk 15%

FavorableFavorableresp 78

P-03500D127 · risk 15%

FavorableFavorableresp 83

P-03415D144 · risk 14%

FavorableFavorableresp 77

P-03190D140 · risk 13%

ImprovingFavorableresp 81

P-03019D142 · risk 10%

ImprovingFavorableresp 85