500 patients67,039 observations150 daysLIVE

120 trajectories in Strong responders

Trajectories

Synthetic demo data

All Strong responders · 120 Moderate responders · 110 Non-responders · 75 Early toxicity · 40 Late toxicity · 40 Delayed loss of response · 45 Resilient responder · 42 High response / high intolerance · 28

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-03485D144 · risk 53%

ImprovingDeterioratingresp 85

P-03348D134 · risk 30%

DecliningDeterioratingresp 84

P-03464D141 · risk 27%

DecliningDeterioratingresp 66

P-03152D120 · risk 20%

ImprovingDeterioratingresp 98

P-03448D139 · risk 17%

FavorableDeterioratingresp 77

P-03281D121 · risk 15%

FavorableImprovingresp 79

P-03276D142 · risk 13%

FavorableImprovingresp 83

P-03466D143 · risk 12%

ImprovingFavorableresp 82

P-03488D144 · risk 10%

FavorableFavorableresp 83

P-03227D147 · risk 8%

FavorableFavorableresp 83

P-03310D146 · risk 6%

DecliningImprovingresp 78

P-03075D148 · risk 4%

FavorableImprovingresp 78