500 patients67,039 observations150 daysLIVE

28 trajectories in High response / high intolerance

Trajectories

Synthetic demo data

All Strong responders · 120 Moderate responders · 110 Non-responders · 75 Early toxicity · 40 Late toxicity · 40 Delayed loss of response · 45 Resilient responder · 42 High response / high intolerance · 28

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-03323D148 · risk 96%

StableUnstableresp 48

P-03341D142 · risk 96%

StableUnstableresp 49

P-03390D138 · risk 96%

UnstableUnstableresp 41

P-03430D121 · risk 92%

StableUnstableresp 45

P-03037D140 · risk 87%

DecliningUnstableresp 43

P-03030D147 · risk 82%

StableUnstableresp 43

P-03049D139 · risk 74%

ImprovingUnstableresp 49

P-03070D147 · risk 73%

StableDeterioratingresp 51

P-03300D150 · risk 73%

StableDeterioratingresp 46

P-03110D142 · risk 67%

DecliningDeterioratingresp 52

P-03103D92 · risk 59%

FavorableStableresp 63

P-03146D140 · risk 58%

ImprovingImprovingresp 53