500 patients67,039 observations150 daysLIVE

45 trajectories in Delayed loss of response

Trajectories

Synthetic demo data

All Strong responders · 120 Moderate responders · 110 Non-responders · 75 Early toxicity · 40 Late toxicity · 40 Delayed loss of response · 45 Resilient responder · 42 High response / high intolerance · 28

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-03277D145 · risk 54%

UnstableDeterioratingresp 41

P-03477D103 · risk 37%

StableDeterioratingresp 56

P-03376D138 · risk 34%

UnstableDeterioratingresp 27

P-03158D147 · risk 30%

UnstableDeterioratingresp 37

P-03014D144 · risk 24%

UnstableDeterioratingresp 32

P-03197D144 · risk 22%

UnstableImprovingresp 41

P-03494D150 · risk 21%

UnstableFavorableresp 38

P-03117D126 · risk 18%

UnstableImprovingresp 35

P-03111D150 · risk 16%

StableImprovingresp 48

P-03433D115 · risk 15%

UnstableDeterioratingresp 34

P-03424D146 · risk 14%

UnstableImprovingresp 41

P-03498D150 · risk 13%

UnstableFavorableresp 31